Associate Professor Dr. Siti Noor Fazliah Binti Mohd Noor
Siti Fatimah Samsurrijal
Mamun Khan Sujon
Muhammad Azrul Zabidi
Nawal Radhiah Abdul Rahman
Zuratul Ain Abdul Hamid
Ruzalina Baharin
Evelyn Wong
Healing process of skin or ulceration underneath a plaster should not be eventful, and it must allow new tissue regeneration. The use of non-resorbable plaster for skin coverings may lead to the patch being difficult to be removed, creates pain upon removal, and may remove skin parts in healing process resulting in more tissue loss. Furthermore, the disposal of non-resorbable patch if not properly monitored, can create environmental problem and increasing carbon footprint due to health care related issues.
Our team proposed SLITUP, a resorbable, bioactive composite film patch that are bacteriostatic and possess ionic elements that is enhanced following sterilisation using gamma irradiation for soft tissue regeneration. Being resorbable, SLITUP reduce the needs for frequent plaster change, hence reducing subject expenditure, cost saving, and it generate tissues while in use without the need for removable.
SLITUP has been tested in primary dermal fibroblasts and cells lines in vitro and subjected to in vivo implantation with and without bacterial induction under the patch on the rabbit skin. SLITUP showed good dermal responses and biodegradation promoting soft tissue healing, hence the potential for further clinical application for treating chronic non-healing ulcers.
