The shortage of organs and tissues worldwide, especially for the trachea, poses a significant public health problem, despite the potential benefits of transplanting severely injured airways or trachea in improving the patients' quality of life. Although tissue engineering has shown promise for tracheal reconstruction, tissue-engineered tracheal grafts' clinical performance falls short of its theoretical potential. Naturally-derived biomaterials lack mechanical support, leading to tracheal collapse, while synthetic trachea offers good mechanical properties but lacks biological cues for cellular engraftment and differentiation. To address these challenges, our team has developed a 3D-printed hybrid trachea prototype called 3D-TechTra. This bioengineered scaffold is made of biocompatible and biodegradable polymers, providing adequate strength and flexibility. We also coated the scaffold surfaces with collagen to enhance its biological properties and improve cellular engraftment. Furthermore, stem cells were pre-engrafted in the scaffold to promote tissue regeneration of the damaged trachea. This innovation, funded by PRGS, has the potential to overcome the limitations of previous tracheal scaffold designs and improve the clinical outcomes of tracheal reconstruction.